Sleep and brain health Archives - Yuval Nir Lab - מעבדת יובל ניר לחקר המוח

Annotated interictal discharges in intracranial EEG sleep data and related machine learning detection scheme

Epilepsy is a neurological disorder characterized by seizures and, between them, brief electrical disturbances known as interictal epileptiform discharges (IEDs). These disturbances, which occur frequently during deep sleep, can disrupt memory and cognition. By training a machine learning model on expert-labeled intracranial EEG recordings from deep brain regions, we developed an automated tool that detects […]

Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy

Using macroelectrode stereo intracranial EEG (iEEG) recordings from a cohort of 46 patients we found that, in the seizure onset zone (SOZ), propagating fast ripple (FR) were more often followed by an epileptiform spike, as compared with non-propagating FR. Propagating FR had a distinct frequency and larger power and were more strongly phase coupled to […]

Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models

Alzheimer’s disease (AD) begins with a decades-long presymptomatic phase, well before the onset of memory decline and global disturbances in sleep architecture. Does hippocampal circuit activity and its homeostasis change at these early stages, and does that occur in particular behavioral states? A collaborative study with the lab of Inna Slutsky combines electrophysiology and calcium imaging […]