Sleep and brain health

SleepEEGpy: a Python-based software integration package to organize preprocessing, analysis, and visualization of sleep EEG data

Analyzing sleep EEG often requires combining multiple tools, creating a fragmented and error-prone workflow that slows research and limits reproducibility. To address this, we developed SleepEEGpy – an open-source Python package that unifies key steps in sleep EEG preprocessing and analysis into one streamlined, user-friendly framework. SleepEEGpy supports data cleaning, ICA, event detection, spectral analysis, and […]

Slow wave synchrony during NREM sleep tracks cognitive impairment in prodromal Alzheimer’s disease

This study revealed that the quality of deep sleep might be a key marker of cognitive decline in individuals with Alzheimer’s disease. As the disease advances from its early stages (amnestic mild cognitive impairment) to full-blown Alzheimer’s, the brain’s ability to produce synchronized slow waves during deep sleep decreases. These slow waves are essential for sleep-related […]

Annotated interictal discharges in intracranial EEG sleep data and related machine learning detection scheme

Epilepsy is a neurological disorder characterized by seizures and, between them, brief electrical disturbances known as interictal epileptiform discharges (IEDs). These disturbances, which occur frequently during deep sleep, can disrupt memory and cognition. By training a machine learning model on expert-labeled intracranial EEG recordings from deep brain regions, we developed an automated tool that detects […]

Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models

Alzheimer’s disease (AD) begins with a decades-long presymptomatic phase, well before the onset of memory decline and global disturbances in sleep architecture. Does hippocampal circuit activity and its homeostasis change at these early stages, and does that occur in particular behavioral states? A collaborative study with the lab of Inna Slutsky combines electrophysiology and calcium imaging […]